The inflammatory response in the Parkinson brain
Identifieur interne : 001A04 ( Main/Exploration ); précédent : 001A03; suivant : 001A05The inflammatory response in the Parkinson brain
Auteurs : Stéphane Hunot [France] ; Andreas Hartmann [France] ; Etienne C. Hirsch [France]Source :
- Clinical Neuroscience Research [ 1566-2772 ] ; 2001.
English descriptors
- KwdEn :
Abstract
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the selective destruction of dopaminergic neurons in the mesencephalon. Other major pathological features of the disease include intracytoplasmic inclusions known as Lewy bodies as well as conspicuous glial reaction consisting of activated microglial cells and astrogliosis. In the past 10 years, tremendous progress has been achieved in our basic understanding of the pathogenesis in this disabling pathology. Among several possible scenarios, accumulating evidence suggests that inflammation-mediated neurotoxicity may play a prominent role in the cascade of events leading to nerve cell death in PD. In this review, we summarize these findings and discuss most recent advances regarding the role of inflammatory processes in the mechanism of nerve cell death in PD.
Url:
DOI: 10.1016/S1566-2772(01)00022-6
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The inflammatory response in the Parkinson brain</title>
<author><name sortKey="Hunot, Stephane" sort="Hunot, Stephane" uniqKey="Hunot S" first="Stéphane" last="Hunot">Stéphane Hunot</name>
</author>
<author><name sortKey="Hartmann, Andreas" sort="Hartmann, Andreas" uniqKey="Hartmann A" first="Andreas" last="Hartmann">Andreas Hartmann</name>
</author>
<author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:39E9354EA59F0BF7759CCAE57B4DCE17A7F2EF30</idno>
<date when="2001" year="2001">2001</date>
<idno type="doi">10.1016/S1566-2772(01)00022-6</idno>
<idno type="url">https://api.istex.fr/document/39E9354EA59F0BF7759CCAE57B4DCE17A7F2EF30/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002883</idno>
<idno type="wicri:Area/Main/Curation">002535</idno>
<idno type="wicri:Area/Main/Exploration">001A04</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The inflammatory response in the Parkinson brain</title>
<author><name sortKey="Hunot, Stephane" sort="Hunot, Stephane" uniqKey="Hunot S" first="Stéphane" last="Hunot">Stéphane Hunot</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U289, Experimental Neurology and Therapeutic, Hôpital de la Salpêtrière, 47 Bd de l'Hôpital, 75013 Paris Cedex 13</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hartmann, Andreas" sort="Hartmann, Andreas" uniqKey="Hartmann A" first="Andreas" last="Hartmann">Andreas Hartmann</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U289, Experimental Neurology and Therapeutic, Hôpital de la Salpêtrière, 47 Bd de l'Hôpital, 75013 Paris Cedex 13</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U289, Experimental Neurology and Therapeutic, Hôpital de la Salpêtrière, 47 Bd de l'Hôpital, 75013 Paris Cedex 13</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">France</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Clinical Neuroscience Research</title>
<title level="j" type="abbrev">CLIRES</title>
<idno type="ISSN">1566-2772</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="2001">2001</date>
<biblScope unit="volume">1</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="434">434</biblScope>
<biblScope unit="page" to="443">443</biblScope>
</imprint>
<idno type="ISSN">1566-2772</idno>
</series>
<idno type="istex">39E9354EA59F0BF7759CCAE57B4DCE17A7F2EF30</idno>
<idno type="DOI">10.1016/S1566-2772(01)00022-6</idno>
<idno type="PII">S1566-2772(01)00022-6</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1566-2772</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CD23</term>
<term>Cytokines</term>
<term>Dopamine</term>
<term>Glial cells</term>
<term>Nitric oxide</term>
<term>Parkinson</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the selective destruction of dopaminergic neurons in the mesencephalon. Other major pathological features of the disease include intracytoplasmic inclusions known as Lewy bodies as well as conspicuous glial reaction consisting of activated microglial cells and astrogliosis. In the past 10 years, tremendous progress has been achieved in our basic understanding of the pathogenesis in this disabling pathology. Among several possible scenarios, accumulating evidence suggests that inflammation-mediated neurotoxicity may play a prominent role in the cascade of events leading to nerve cell death in PD. In this review, we summarize these findings and discuss most recent advances regarding the role of inflammatory processes in the mechanism of nerve cell death in PD.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Hunot, Stephane" sort="Hunot, Stephane" uniqKey="Hunot S" first="Stéphane" last="Hunot">Stéphane Hunot</name>
</region>
<name sortKey="Hartmann, Andreas" sort="Hartmann, Andreas" uniqKey="Hartmann A" first="Andreas" last="Hartmann">Andreas Hartmann</name>
<name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name>
<name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A04 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A04 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:39E9354EA59F0BF7759CCAE57B4DCE17A7F2EF30 |texte= The inflammatory response in the Parkinson brain }}
This area was generated with Dilib version V0.6.23. |